For the digital transformation of European manufacturing SMEs, the Horizon 2020 ICT Innovation for Manufacturing SMEs (I4MS) programme was a flagship. Phase IV of the programme, in particular, focused on Digital Innovation Hubs (DIHs) and cutting-edge technologies such as Artificial Intelligence and digital twins. On this wave, the interregional project AI REGIO was funded, focusing on the establishment of a European network of DIHs and the application of Artificial Intelligence solutions to manufacturing SMEs. The AI REGIO project developed an innovative methodology to support the growth and collaboration of DIHs through the analysis of service portfolios and customer journeys, set up a toolkit focused on AI4EU, and defined the network ‘Didactic Factories and their TEchnology and REgulatory Sandboxes’ (TERESA).With the aim of coordinating these results and moving them towards the concept of Industry 5. 0, with the development of AI cloud technologies towards Edge Computing, with the evolution of Horizon2020 into Horizon Europe and with the evolution of Digital Europe programmes such as EDIH, Data Spaces and AI TEFs (Testing and Experimentation Facilities) for the manufacturing sector, AI REDGIO 5.0 will continue to promote the adoption of Artificial Intelligence technologies in manufacturing SMEs. The I4MS partnership and the AI REGIO project partnership involving the Vanguard regions and the different DIHs will therefore be updated and extended with the AI REDGIO 5.0 project, in order to enable a competitive ‘AI-at-the-Edge’ digital transformation of manufacturing SMEs in Industry 5.0 sensitising consumers to a more conscious behaviour to ensure sustainability.